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Research the Wiegmann surname using fold3 Military Archives and view images of original Wiegmann Military records. Did you know that there are currently 10 people with the Wiegmann surname in the UK? Wiegmann is now ranked number for popularity in the UK. Wiegmann Family Tree Databases Another way to build your tree quickly is to use the research other people have already done. This can help to confirm or refute your own deductions - however, be wary of taking this data at face value as other researchers may not have been as meticulous as you.

Always try to back up deductions with some definitive sources rather than relying too heavily on others. Search the WikiTree database for user contributed records for Bettina Wiegmann. Wiegmann: Our idea is to populate all artificial surfaces that trigger foreign body reactions such as the formation of a thrombus with endothelial cells - that means, we populate the hollow fiber membranes and tubing.

Endothelial cells line the interior surface of blood vessels in the human body and are hemocompatible, thus preventing thrombus formation. Since the body's own endothelial cells are not available in sufficient quantities, we use endothelial cells that are not endogenous to the body. Another option is to use so-called induced pluripotent stem cells to develop an unlimited source of endothelial cells.

To recap, we make the artificial surfaces biological with the endothelial cells to create a so-called biohybrid lung, which lasts a lifetime and eliminates the need for anticoagulation. The goal is to implant an artificial — biohybrid — lung in patients. What are the next steps to make this a reality? Wiegmann: One step is to ensure that the endothelial cells adhere firmly enough to the hollow fiber membranes.

An implanted biohybrid lung would have to withstand the blood flow of four to six liters each minute. The endothelial cells must be able to withstand the frictional stress caused by this blood flow. Current ECMO systems measure about 15x15x5 centimeters in size, making implantation in the body impossible.

This necessitates miniaturization, which should ideally be tailored to the individual patient as each patient requires a different gas exchange surface area to support the lungs depending on the type and stage of the disease. The membrane size enables us to control the biohybrid lung capacity and performance. Miniaturization should therefore keep individualization in mind.